P-180 Gastric cancer in Albania: Epidemiological, clinical and pathological characteristics

Gastric cancer incidence and mortality varies between Mediterranean countries. As the diet is considered one of healthiest diet, gastric still fourth most common causes death from in Albania. The aim study was to analyze epidemiological, clinical pathological characteristic Albania, a country. Demographic, histopathological, data 306 treated Clinic Oncology at University Hospital Center Mother Teresa, during 2016-2019 were retrospectively analyzed, identify characteristics pattern Overall survival (OS) disease-free (DFS) evaluated. Statistical analysis done using SPSS version 26 (SPSS, Chicago, IL). patients’mean age 60 ± 10 years (range 26-87 years). Male female rate 3.6:1. Forty-one percent patient group 56-65 old, 30% over 66 old 9% under 45 old. Data showed quite homogeneous distribution Tirana, coastal central region with 33%, 26.8% 29.4% respectively only 5% mountain region. Median follow up 48± 14 months. Eight patients had family history for 87.5% 65 At diagnosis 19.2% have metastatic disease. Forty diagnosed stage III 29.5% II cancer. Sixty-seven patient’s IV 56-75 Total gastrectomy subtotal resection performed 28.7% 48.4% respectively, 21.9% inoperable. Sixteen (8.9%) R1 resection. Incomplete node dissection 62,4% patients, 7.2% D1 30.4% D2 dissection. Adenocarcinoma found 93.8% 5.9% signed cell. Most (61.3%) well differentiated (G3) According Lauren classification 24.8% intestinal type, 27.3% diffuse type 47.9% mix type. Vascular invasion perineural present 54.9% 55.9%, respectively. Main primary tumor location antro-pyloric 41.7% corpus 15.4%. Less frequent cardia 2%. Patients neoadjuvant treatment 7.8%, adjuvant 70%, palliative 12.8% 28.1% concomitant chemoradiotherapy. median OS DFS 14.8 9 months male 17 7.8 female, No significant correlation gender related DFS, but higher risk progressive disease (PD) compared (OR=1.4, 95% CI=0.86-2.4), p=0.3). Positive treatment, p=0.032. remains challenge early treatment. This represents first evaluation on demographic Albania its management. Further sub would be necessary understand factors that may determine advance order promote screening program groups regions incidence.